Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL1966431

O=C(O)CC(=O)C(=O)O.O=C(O)CCC(=O)C(=O)O

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 5/20 0.78
OR51E2 Q9H255 2/20 0.78
MAPK1 P28482 1/20 0.78
SLC13A3 Q8WWT9 1/20 0.78
LMNA P02545 4/20 0.50
ALKBH5 Q6P6C2 1/20 0.50
SUCNR1 Q9BXA5 1/20 0.50
LDHA P00338 1/20 0.42
SRR Q9GZT4 1/20 0.42
PHF8 Q9UPP1 6/20 0.42
KDM2A Q9Y2K7 6/20 0.42
KDM4E B2RXH2 4/20 0.42
KDM5C P41229 4/20 0.42
KDM6B O15054 2/20 0.42
FOLH1 Q04609 1/20 0.42
SLC15A2 Q16348 1/20 0.39
SLC22A6 Q4U2R8 1/20 0.38
HAO1 Q9UJM8 1/20 0.37
TSHR P16473 1/20 0.36
NFKB1 P19838 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxaloacetate SCHEMBL5614074 0.94 EGLN1 (0.67) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL4738799 0.92 EGLN1 (0.82) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL1131520 0.91 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL8974974 0.91 EGLN1 (0.93) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30029036 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL3776640 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL30208560 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL932116 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL29783374 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA
Alpha-Ketoglutaric Acid SCHEMBL17127347 0.88 EGLN1 (1.00) EGLN1OR51E2MAPK1SLC13A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3534875-A1 COSMETIC COMPOSITIONS CONTAINING QUINONES AND THEIR TOPICAL USE ON SKIN AND HAIR Repairogen Corp (US) 2019-09-11 EP disclosed
EP-3298156-A1 AMINO ACID PRODUCTION Evonik Degussa GmbH (DE) 2018-03-28 EP disclosed
WO-2017009009-A1 AMINO ACID PRODUCTION EVONIK DEGUSSA GMBH (DE) 2017-01-19 WO disclosed
EP-3081639-A1 Acyl amino acid production Evonik Degussa GmbH (DE) 2016-10-19 EP disclosed
EP-2910639-A1 Plants having enhanced yield-related traits and a method for making the same BASF Plant Science GmbH (DE) 2015-08-26 EP disclosed
US-8163475-B2 Methods for diagnosis and prognosis of psychotic disorders THE MCLEAN HOSPITAL CORPORATION (US) 2012-04-24 US disclosed
EP-2334797-A1 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME BASF Plant Science GmbH (DE) 2011-06-22 EP disclosed
WO-2010034681-A1 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR MAKING THE SAME BASF PLANT SCIENCE GMBH (DE) 2010-04-01 WO disclosed
EP-1902319-B1 DIAGNOSTIC METHOD FOR BRAIN DAMAGE-RELATED DISORDERS UNIV GENEVE (CH) 2010-01-20 EP disclosed
US-20080009010-A1 Methods for diagnosis and prognosis of psychotic disorders THE MCLEAN HOSPITAL CORPORATION (US) 2008-01-10 US disclosed
EP-1789547-A1 THE USE OF PHOSPHOKETOLASE FOR PRODUCING USEFUL METABOLITES Ajinomoto Co., Inc. (JP) 2007-05-30 EP disclosed
WO-2006016705-A1 THE USE OF PHOSPHOKETOLASE FOR PRODUCING USEFUL METABOLITES AJINOMOTO CO., INC. (JP) 2006-02-16 WO disclosed
EP-0387697-A2 Determination of aminotranferases ABBOTT LABORATORIES (US) 1990-09-19 EP disclosed