Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29106481 | 0.78 | L3MBTL1 (0.44) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL19364256 | 0.77 | HTT (0.42) | SMN1; SMN2MAPTNOTUMALDH1A1 | |
| SCHEMBL30841911 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1TRPV3KCNH2CYP2C9 | |
| SCHEMBL24468414 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1TRPV3KCNH2CYP2C9 | |
| SCHEMBL5644659 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL28670107 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL23148685 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL29685778 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL29637301 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 | |
| SCHEMBL16705085 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914597-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2017-12-06 | — | — | EP | disclosed |