Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | IL1B | P01584 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23148685 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL10807143 | 0.78 | NUDT1 (0.38) | SMN1; SMN2IL1B | |
| SCHEMBL29685778 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL16705085 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL5644659 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL28670107 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL17157315 | 0.77 | CYP1A2 (0.53) | L3MBTL1CYP1A2POLBMAPK1MAPT | |
| SCHEMBL19664476 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1CYP1A2IL1BPOLB | |
| SCHEMBL30956492 | 0.74 | HTT (0.45) | SMN1; SMN2POLBMAPTALDH1A1MEN1 | |
| SCHEMBL25220258 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774741-B1 | ANTIMALARIAL HEXAHYDROPYRIMIDINE ANALOGUES | UCB Biopharma SRL (BE) | 2022-06-08 | — | — | EP | disclosed |