Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705085 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1HDAC1HDAC6HDAC5 | |
| SCHEMBL24637809 | 0.84 | IL1B (0.39) | SMN1; SMN2L3MBTL1HDAC1HDAC6HDAC5 | |
| SCHEMBL17562270 | 0.78 | HDAC1 (0.36) | SMN1; SMN2HDAC1HDAC6HDAC5IL1B | |
| SCHEMBL29637301 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BCYP1A2POLB | |
| SCHEMBL28670107 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BCYP1A2POLB | |
| SCHEMBL23148685 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BCYP1A2POLB | |
| SCHEMBL5644659 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1IL1BCYP1A2POLB | |
| SCHEMBL19664476 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1IL1BCYP1A2POLB | |
| SCHEMBL13576998 | 0.75 | HTT (0.46) | SMN1; SMN2HDAC1HDAC6HDAC5POLB | |
| SCHEMBL29761634 | 0.75 | HTT (0.46) | SMN1; SMN2HDAC1HDAC6HDAC5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251624-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | Amgen, Inc (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022115377-A1 | TRICYCLIC CARBOXAMIDE DERIVATIVES AS PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-02 | — | — | WO | disclosed |