Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 16/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665726 | 0.86 | STK17B (0.56) | STK17BSTK17A | |
| SCHEMBL29802472 | 0.86 | STK17B (0.56) | STK17BSTK17A | |
| SCHEMBL29290149 | 0.82 | STK17A (0.44) | STK17BSTK17A | |
| SCHEMBL19665725 | 0.81 | MAPK8 (0.34) | MAPK8MAPK9ADORA3MAPK10CHEK1 | |
| SCHEMBL19665714 | 0.81 | SIRT5 (0.53) | SIRT5STK17A | |
| SCHEMBL28652855 | 0.81 | JAK3 (0.38) | STK17BSTK17AMAPK8MAPK9ADORA3 | |
| SCHEMBL19665717 | 0.80 | JAK1 (0.37) | MAPK8MAPK9ADORA3MAPK10CHEK1 | |
| SCHEMBL19665747 | 0.80 | MAPK8 (0.37) | MAPK8MAPK9ADORA3MAPK10 | |
| SCHEMBL29290162 | 0.80 | JAK1 (0.35) | STK17BSTK17AMAPK8MAPK9ADORA3 | |
| SCHEMBL28639902 | 0.74 | JAK3 (0.38) | MAPK8MAPK9ADORA3MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464287-B1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2022-06-08 | — | — | EP | disclosed |
| US-11344554-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2022-05-31 | — | — | US | disclosed |
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2020-10-22 | — | — | US | disclosed |
| US-10736899-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2020-08-11 | — | — | US | disclosed |
| US-10420771-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3464287-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | Celgene Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| CN-109563095-A | Animal and people's anti-malarial agents | 细胞基因公司 | 2019-04-02 | — | — | CN | disclosed |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2018-10-04 | — | — | US | disclosed |
| US-10016436-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| WO-2017210399-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION (US) | 2017-12-07 | — | — | WO | disclosed |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | SIRT5 2163/4885STK17B 3629/4885STK17A 3295/4885 |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, NUDT1, UMPS | SIRT5 2434/4885STK17B 3111/4885STK17A 2909/4885 |
| US-10420771-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | SIRT5 2151/4885STK17B 3617/4885STK17A 3241/4885 |
| US-10736899-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | SIRT5 2163/4885STK17B 3629/4885STK17A 3295/4885 |
| US-10016436-B2 | Animal and human anti-malarial agents | HPRT1, NUDT1, UMPS | SIRT5 2434/4885STK17B 3111/4885STK17A 2909/4885 |
| US-11344554-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | SIRT5 2163/4885STK17B 3629/4885STK17A 3295/4885 |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | SIRT5 2163/4885STK17B 3629/4885STK17A 3295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.