Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.34 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18270538 | 0.90 | LMNA (0.42) | TP53CA2LMNANFKB1NFKB2 | |
| SCHEMBL18270539 | 0.85 | LMNA (0.42) | TP53CA2LMNANFKB1NFKB2 | |
| SCHEMBL18268179 | 0.78 | TP53 (0.40) | TP53CA2LMNAALDH1A1CYP2D6 | |
| SCHEMBL18268181 | 0.78 | LMNA (0.38) | TP53CA2LMNATUBB4ATUBB | |
| SCHEMBL19669616 | 0.73 | KDM4E (0.41) | ERN1CA2LMNANFKB1NFKB2 | |
| SCHEMBL19669613 | 0.73 | KDM4E (0.41) | ERN1CA2LMNANFKB1NFKB2 | |
| SCHEMBL19669617 | 0.73 | KDM4E (0.41) | ERN1CA2LMNANFKB1NFKB2 | |
| SCHEMBL18268205 | 0.71 | ALDH1A1 (0.47) | TP53CA2LMNAALDH1A1MAPT | |
| SCHEMBL17001498 | 0.66 | ALDH1A1 (0.40) | TP53CA2LMNAALDH1A1MAPT | |
| SCHEMBL18268180 | 0.64 | CA2 (0.44) | CA2LMNAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834525-B2 | Inhibitors of paxillin function and related compositions and methods | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2017-12-05 | — | — | US | disclosed |