Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965654 | 0.91 | EGLN1 (0.51) | EGLN3HIF1AEGLN1EGLN2 | |
| SCHEMBL1969288 | 0.85 | EGLN1 (0.53) | EGLN3HIF1AEGLN1EGLN2HDAC1 | |
| SCHEMBL1965300 | 0.82 | P2RX7 (0.42) | HDAC1HDAC8HDAC6 | |
| SCHEMBL3731074 | 0.80 | EGLN3 (0.51) | EGLN3HIF1AEGLN1EGLN2 | |
| SCHEMBL1967789 | 0.78 | EGLN1 (0.44) | EGLN3HIF1AEGLN1EGLN2 | |
| SCHEMBL3727894 | 0.75 | EGLN1 (0.53) | EGLN3HIF1AEGLN1EGLN2 | |
| SCHEMBL1967018 | 0.75 | L3MBTL1 (0.44) | EGLN1 | |
| SCHEMBL1967854 | 0.75 | EGLN3 (0.52) | EGLN3HIF1AEGLN1EGLN2 | |
| SCHEMBL1964132 | 0.73 | KMT2A (0.45) | — | |
| SCHEMBL8248114 | 0.72 | EGLN1 (0.76) | EGLN3HIF1AEGLN1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |