Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967018 | 0.88 | L3MBTL1 (0.44) | EGLN1KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL1969288 | 0.86 | EGLN1 (0.53) | EGLN1EGLN2EGLN3HDAC1HDAC8 | |
| SCHEMBL1963992 | 0.85 | KDM4E (0.45) | EGLN1EGLN2EGLN3HDAC1HDAC8 | |
| SCHEMBL3732846 | 0.83 | EGLN1 (0.38) | EGLN1EGLN2EGLN3PTGER4HDAC1 | |
| SCHEMBL3732845 | 0.83 | EGLN1 (0.38) | EGLN1EGLN2EGLN3PTGER4HDAC1 | |
| SCHEMBL1966135 | 0.73 | L3MBTL1 (0.44) | EGLN1KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL1966134 | 0.73 | L3MBTL1 (0.44) | EGLN1KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL1965654 | 0.72 | EGLN1 (0.51) | EGLN1EGLN2EGLN3 | |
| SCHEMBL1968417 | 0.71 | EGLN3 (0.44) | EGLN1EGLN2EGLN3HDAC1HDAC8 | |
| SCHEMBL2384067 | 0.70 | L3MBTL1 (0.52) | EGLN1EGLN2EGLN3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | claimed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | claimed |
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |