Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670156 | 0.91 | PRMT5 (0.40) | PRMT5WDR77SIRT2CARM1ADRB3 | |
| SCHEMBL16238381 | 0.83 | PRMT5 (0.41) | PRMT5WDR77SIRT2CARM1ADRB3 | |
| SCHEMBL16238383 | 0.83 | PRMT5 (0.41) | PRMT5WDR77SIRT2CARM1ADRB3 | |
| SCHEMBL16238378 | 0.83 | PRMT5 (0.41) | PRMT5WDR77SIRT2CARM1ADRB3 | |
| SCHEMBL19670575 | 0.83 | EGFR (0.32) | ALDH1A1ADORA2A | |
| SCHEMBL19670234 | 0.81 | FGFR4 (0.35) | PRMT5WDR77CARM1ADRB3ADRB2 | |
| SCHEMBL19670122 | 0.81 | GRM5 (0.34) | — | |
| SCHEMBL19670181 | 0.80 | RAF1 (0.35) | — | |
| SCHEMBL19670160 | 0.80 | PRMT5 (0.42) | PRMT5WDR77SIRT2CARM1TSHR | |
| SCHEMBL19670588 | 0.79 | FGFR4 (0.38) | PRMT5WDR77CARM1ADRB3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |