Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365372 | 0.86 | FGFR4 (0.40) | GSK3BDYRK1ARECQLSMN1; SMN2NTRK1 | |
| SCHEMBL19365613 | 0.85 | FAAH (0.40) | GSK3BDYRK1ANTRK1FAAHPTGS1 | |
| SCHEMBL16238195 | 0.84 | KIT (0.39) | GSK3BDYRK1ARECQLSMN1; SMN2NTRK1 | |
| SCHEMBL19706135 | 0.84 | FAAH (0.36) | GSK3BDYRK1ARECQLSMN1; SMN2NTRK1 | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | GSK3BDYRK1AWNT3APTGS1PTGS2 | |
| SCHEMBL19365317 | 0.84 | GSK3B (0.39) | GSK3BDYRK1ASMN1; SMN2FAAHPTGS1 | |
| SCHEMBL19365445 | 0.83 | TRPM8 (0.43) | GSK3BDYRK1APTGS1PTGS2TRPV1 | |
| SCHEMBL19365426 | 0.83 | GSK3B (0.41) | GSK3BDYRK1ANTRK1PTGS1PTGS2 | |
| SCHEMBL19670375 | 0.83 | TRPV1 (0.41) | GSK3BDYRK1ASMN1; SMN2ALDH1A1KIT | |
| SCHEMBL19670187 | 0.82 | MTOR (0.36) | GSK3BDYRK1ARECQLSMN1; SMN2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |