Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MELK | Q14680 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670278 | 0.91 | MCHR1 (0.37) | MCHR1HRH4HRH3P2RX7MELK | |
| SCHEMBL19670280 | 0.88 | MCHR1 (0.37) | MCHR1MAPTHRH4HRH3P2RX7 | |
| SCHEMBL19670269 | 0.87 | MCHR1 (0.38) | MCHR1HRH4HRH3P2RX7MAP4K4 | |
| SCHEMBL19670277 | 0.83 | MCHR1 (0.37) | MCHR1HRH4HRH3MEN1KMT2A | |
| SCHEMBL17618523 | 0.82 | MCHR1 (0.38) | MCHR1PRMT5WDR77HRH4HRH3 | |
| SCHEMBL19670447 | 0.82 | PDE10A (0.39) | MCHR1HRH4HRH3P2RX7MAP4K4 | |
| SCHEMBL19364859 | 0.80 | TRPV3 (0.39) | PRMT5WDR77MAPTKMT2AMAP4K4 | |
| SCHEMBL16776030 | 0.80 | PRMT5 (0.37) | MCHR1PRMT5WDR77HRH4HRH3 | |
| SCHEMBL19670276 | 0.79 | JAK2 (0.40) | MCHR1MAPTHRH4HRH3MEN1 | |
| SCHEMBL17618524 | 0.73 | LCK (0.39) | MCHR1HRH4HRH3P2RX7MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |