SCHEMBL19670447 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	PDE10A	Q9Y233	4/20	0.39

▸	HRH4	Q9H3N8	3/20	0.39

▸	HRH3	Q9Y5N1	3/20	0.39

▸	MCHR1	Q99705	3/20	0.38

▸	MAP4K4	O95819	2/20	0.37

▸	P2RX7	Q99572	2/20	0.35

▸	ATR	Q13535	2/20	0.35

▸	KLKB1	P03952	1/20	0.35

▸	KLK1	P06870	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL19670269	0.86	MCHR1 (0.38)	PDE10AHRH4HRH3MCHR1MAP4K4
SCHEMBL19670276	0.83	JAK2 (0.40)	PDE10AHRH4HRH3MCHR1MAP4K4
SCHEMBL19670272	0.82	MCHR1 (0.37)	HRH4HRH3MCHR1MAP4K4P2RX7
SCHEMBL19670277	0.82	MCHR1 (0.37)	HRH4HRH3MCHR1MAP4K4P2RX7
SCHEMBL17618530	0.82	PDE10A (0.40)	PDE10AHRH4HRH3MCHR1MAP4K4
SCHEMBL19670280	0.82	MCHR1 (0.37)	HRH4HRH3MCHR1MAP4K4P2RX7
SCHEMBL19670278	0.82	MCHR1 (0.37)	HRH4HRH3MCHR1MAP4K4P2RX7
SCHEMBL19365455	0.78	POLB (0.39)	MAP4K4
SCHEMBL16776031	0.77	MCHR1 (0.39)	PDE10AHRH4HRH3MCHR1MAP4K4
SCHEMBL19706220	0.72	MAP3K5 (0.35)	PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-9834558-B2	Substituted bridged urea analogs as sirtuin modulators	GLAXOSMITHKLINE LLC (US)	2017-12-05	—	—	US	disclosed