Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670277 | 0.86 | MCHR1 (0.37) | JAK1HRH4HRH3MAP4K4MCHR1 | |
| SCHEMBL19670447 | 0.83 | PDE10A (0.39) | HRH4HRH3MAP4K4MCHR1PDE10A | |
| SCHEMBL17618527 | 0.82 | JAK2 (0.40) | JAK2JAK1JAK3HRH4HRH3 | |
| SCHEMBL19670280 | 0.82 | MCHR1 (0.37) | HRH4HRH3MAP4K4MCHR1P2RX7 | |
| SCHEMBL19670269 | 0.81 | MCHR1 (0.38) | HRH4HRH3MAP4K4MCHR1PDE10A | |
| SCHEMBL19670272 | 0.79 | MCHR1 (0.37) | HRH4HRH3MAP4K4MCHR1P2RX7 | |
| SCHEMBL19365447 | 0.78 | MAP4K4 (0.39) | MAP4K4MEN1LMNAGAAKMT2A | |
| SCHEMBL19670278 | 0.78 | MCHR1 (0.37) | HRH4HRH3MAP4K4MCHR1P2RX7 | |
| SCHEMBL20633442 | 0.75 | MAP4K4 (0.39) | JAK2JAK1JAK3HRH4HRH3 | |
| SCHEMBL17618532 | 0.68 | PRNP (0.39) | JAK1HRH4HRH3MAP4K4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |