Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670276 | 0.86 | JAK2 (0.40) | MCHR1HRH4HRH3MAP4K4JAK1 | |
| SCHEMBL19670272 | 0.83 | MCHR1 (0.37) | MCHR1HRH4HRH3MAP4K4P2RX7 | |
| SCHEMBL19670280 | 0.83 | MCHR1 (0.37) | MCHR1HRH4HRH3MAP4K4P2RX7 | |
| SCHEMBL19670278 | 0.83 | MCHR1 (0.37) | MCHR1HRH4HRH3MAP4K4P2RX7 | |
| SCHEMBL19670447 | 0.82 | PDE10A (0.39) | MCHR1HRH4HRH3MAP4K4P2RX7 | |
| SCHEMBL17618532 | 0.82 | PRNP (0.39) | MCHR1HRH4HRH3MAP4K4JAK1 | |
| SCHEMBL19670269 | 0.81 | MCHR1 (0.38) | MCHR1HRH4HRH3MAP4K4P2RX7 | |
| SCHEMBL19364892 | 0.80 | MAP4K4 (0.38) | MAP4K4SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL20633224 | 0.78 | MCHR1 (0.38) | MCHR1HRH4HRH3MAP4K4JAK1 | |
| SCHEMBL19706196 | 0.76 | MCHR1 (0.39) | MCHR1HRH4HRH3MAP4K4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |