Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365394 | 0.91 | FAAH (0.39) | FAAHCSNK1DCSNK1EFGFR4FFAR4 | |
| SCHEMBL19670631 | 0.89 | FAAH (0.35) | FAAHCSNK1DCSNK1EFGFR4LRRK2 | |
| SCHEMBL19670438 | 0.89 | FAAH (0.36) | FAAHCSNK1DCSNK1EFGFR4FFAR4 | |
| SCHEMBL19670310 | 0.86 | FAAH (0.38) | FAAHCSNK1DCSNK1EFGFR4 | |
| SCHEMBL17618531 | 0.86 | FAAH (0.40) | FAAHCSNK1DCSNK1EFGFR4FFAR4 | |
| SCHEMBL17618558 | 0.86 | FAAH (0.40) | FAAHCSNK1DCSNK1EFGFR4FFAR4 | |
| SCHEMBL19365442 | 0.85 | FAAH (0.37) | FAAHCSNK1DCSNK1EFGFR4LRRK2 | |
| SCHEMBL19670584 | 0.82 | FAAH (0.41) | FAAHCSNK1DCSNK1EFGFR4RPS6KA2 | |
| SCHEMBL19365384 | 0.81 | FGFR4 (0.43) | FAAHCSNK1DCSNK1EFGFR4FFAR4 | |
| SCHEMBL19365725 | 0.80 | FGFR4 (0.37) | FAAHCSNK1DCSNK1EFGFR4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |