Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670279 | 0.89 | FAAH (0.38) | FAAHCSNK1DCSNK1EFGFR4RPS6KA2 | |
| SCHEMBL19670182 | 0.87 | CREBBP (0.34) | CREBBPFGFR4ALOX5APMAP3K12IDH1 | |
| SCHEMBL17618537 | 0.85 | FAAH (0.38) | FAAHCREBBPCSNK1DCSNK1EFGFR4 | |
| SCHEMBL19670310 | 0.84 | FAAH (0.38) | FAAHCSNK1DCSNK1EFGFR4MTOR | |
| SCHEMBL19670334 | 0.81 | FGFR4 (0.36) | FAAHFGFR4MAP3K12PDK1PDK2 | |
| SCHEMBL19670584 | 0.81 | FAAH (0.41) | FAAHCSNK1DCSNK1EFGFR4RPS6KA2 | |
| SCHEMBL19365757 | 0.80 | FGFR4 (0.42) | FAAHCREBBPCSNK1DCSNK1EFGFR4 | |
| SCHEMBL19365394 | 0.80 | FAAH (0.39) | FAAHCSNK1DCSNK1EFGFR4RPS6KA2 | |
| SCHEMBL19670631 | 0.80 | FAAH (0.35) | FAAHCSNK1DCSNK1EFGFR4RPS6KA2 | |
| SCHEMBL19365756 | 0.78 | VCP (0.38) | FAAHCREBBPMAP3K12IDH1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |