Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365442 | 0.93 | FAAH (0.37) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL19670584 | 0.91 | FAAH (0.41) | FAAHFGFR4CSNK1DCSNK1EPDK1 | |
| SCHEMBL19670279 | 0.91 | FAAH (0.38) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL19365725 | 0.89 | FGFR4 (0.37) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL19365721 | 0.89 | FGFR4 (0.37) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL19365384 | 0.89 | FGFR4 (0.43) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL17618531 | 0.88 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL17618558 | 0.88 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ELRRK2 | |
| SCHEMBL19365436 | 0.86 | VCP (0.41) | FAAHPDE10A | |
| SCHEMBL19365434 | 0.86 | VCP (0.41) | FAAHPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |