Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365394 | 0.91 | FAAH (0.39) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 | |
| SCHEMBL19365442 | 0.89 | FAAH (0.37) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 | |
| SCHEMBL19670471 | 0.89 | POLQ (0.35) | POLQHCRTR2CNR1TRPV3ROCK2 | |
| SCHEMBL19365745 | 0.87 | DHFR (0.38) | FAAHJAK2CAMK2DTRPV3IRAK4 | |
| SCHEMBL19670233 | 0.87 | FAAH (0.39) | FAAHFGFR4CSNK1DCSNK1EPDK1 | |
| SCHEMBL16776041 | 0.86 | FAAH (0.40) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 | |
| SCHEMBL17618442 | 0.86 | FAAH (0.41) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 | |
| SCHEMBL19670153 | 0.85 | VCP (0.41) | FAAHFGFR4JAK2CAMK2DTRPV3 | |
| SCHEMBL19670373 | 0.85 | KDR (0.41) | FAAHFGFR4CSNK1DCSNK1EIRAK4 | |
| SCHEMBL19670266 | 0.85 | FGFR4 (0.41) | FAAHFGFR4CSNK1DCSNK1ERPS6KA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |