Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.36 |
| ▸ | MAOA | P21397 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670632 | 0.88 | RHOA (0.39) | RHOAKDM1AMAPTBRAFMAOB | |
| SCHEMBL19365836 | 0.85 | MAPT (0.49) | KDM1AMAPTBRAFFYNJAK2 | |
| SCHEMBL19670282 | 0.85 | RHOA (0.40) | RHOAKDM1AMAPTBRAFMAOB | |
| SCHEMBL19365389 | 0.84 | FYN (0.44) | KDM1AMAPTBRAFFYNMAOB | |
| SCHEMBL19365674 | 0.83 | RHOA (0.43) | RHOAKDM1AMAPTBRAFFYN | |
| SCHEMBL19706268 | 0.83 | RHOA (0.46) | RHOAKDM1ABRAFFYNMAOB | |
| SCHEMBL16238714 | 0.82 | RHOA (0.43) | RHOAKDM1AMAPTBRAFFYN | |
| SCHEMBL19706297 | 0.82 | RHOA (0.51) | RHOAMAPTBRAFTRPV1BRD4 | |
| SCHEMBL19865057 | 0.81 | RHOA (0.41) | RHOAKDM1AMAPTBRAFFYN | |
| SCHEMBL19365474 | 0.81 | MAPT (0.42) | KDM1AMAPTFYNMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |