Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631824 | 0.90 | SMN1; SMN2 (0.35) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19706061 | 0.87 | KDM1A (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19365814 | 0.86 | NPC1 (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19365514 | 0.85 | ALDH1A1 (0.37) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19670378 | 0.83 | RAB9A (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19670636 | 0.83 | RAB9A (0.44) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19365577 | 0.82 | GRM5 (0.38) | SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL19365329 | 0.82 | RAB9A (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19365801 | 0.81 | RAB9A (0.38) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPK1 | |
| SCHEMBL19670445 | 0.80 | GRM5 (0.39) | SMN1; SMN2MAPK1FYNMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |