Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778738 | 0.91 | LIPG (0.36) | RPS6KB1KDM4EHPGDKDM1AMAOA | |
| SCHEMBL17618494 | 0.90 | HPGDS (0.39) | HSD17B10KDM4EHPGDMAPK1HPGDS | |
| SCHEMBL19689650 | 0.89 | GPR52 (0.35) | RPS6KB1KDM4EHPGDKDM1AMAOA | |
| SCHEMBL19706655 | 0.89 | KDM1A (0.34) | RPS6KB1NTRK1KDM1AMAOAMAOB | |
| SCHEMBL17768097 | 0.89 | KDM1A (0.34) | RPS6KB1NTRK1KDM1AMAOAMAOB | |
| SCHEMBL17618435 | 0.89 | GRM5 (0.36) | MAPK1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL17618367 | 0.88 | FAAH (0.41) | PHGDHRPS6KB1KDM1AMAOAMAOB | |
| SCHEMBL17618356 | 0.88 | NPC1 (0.38) | PHGDHHSD17B10KDM1AMAOAMAOB | |
| SCHEMBL19706218 | 0.88 | FAAH (0.41) | PHGDHRPS6KB1KDM1AMAOAMAOB | |
| SCHEMBL17618601 | 0.88 | POLQ (0.38) | MAPK1TP53TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |