Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 7/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365662 | 0.88 | HTR1F (0.36) | CACNA1GCACNA1HCACNA1IHTR1FFAAH | |
| SCHEMBL19670244 | 0.85 | HTR2A (0.45) | CACNA1GCACNA1HCACNA1IHTR2AHTR2C | |
| SCHEMBL19670174 | 0.81 | HDAC2 (0.39) | CACNA1GCACNA1HCACNA1IKCNH2 | |
| SCHEMBL19670514 | 0.79 | KARS1 (0.34) | CACNA1GCACNA1HCACNA1IABL1 | |
| SCHEMBL19670507 | 0.79 | KARS1 (0.34) | CACNA1GCACNA1HCACNA1IABL1 | |
| SCHEMBL17618542 | 0.78 | ABL1 (0.35) | HTR1FFAAHABL1 | |
| SCHEMBL19670597 | 0.77 | NPC1 (0.40) | CACNA1GCACNA1HCACNA1IHTTNPC1 | |
| SCHEMBL19670186 | 0.75 | CYP3A4 (0.37) | — | |
| SCHEMBL19865071 | 0.73 | HTR2C (0.47) | NPC1RAB9AHTR2AHTR2C | |
| SCHEMBL19670644 | 0.73 | HSD17B10 (0.37) | ALDH1A1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |