Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.45 |
| ▸ | HTR2C | P28335 | 11/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 8/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 8/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19865071 | 0.88 | HTR2C (0.47) | HTR2AHTR2C | |
| SCHEMBL19670291 | 0.85 | CACNA1G (0.36) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19865050 | 0.82 | HTR2C (0.40) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670597 | 0.82 | NPC1 (0.40) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19365527 | 0.82 | HTR2C (0.50) | HTR2AHTR2C | |
| SCHEMBL19670527 | 0.81 | NAMPT (0.46) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670393 | 0.80 | ABL1 (0.42) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670179 | 0.80 | HTR2C (0.46) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670388 | 0.80 | CACNA1G (0.46) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670589 | 0.79 | HTR2C (0.42) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |