Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 7/20 | 0.32 |
| ▸ | RAF1 | P04049 | 5/20 | 0.32 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670507 | 1.00 | KARS1 (0.34) | KARS1KLKB1KLK1DYRK1ACACNA1G | |
| SCHEMBL19669954 | 0.88 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19669950 | 0.88 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670487 | 0.87 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19670396 | 0.87 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19670006 | 0.85 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL17618681 | 0.85 | KARS1 (0.35) | KARS1KLKB1KLK1DYRK1AABL1 | |
| SCHEMBL17618689 | 0.85 | KARS1 (0.35) | KARS1KLKB1KLK1DYRK1AABL1 | |
| SCHEMBL19670010 | 0.84 | CLK2 (0.34) | KARS1DYRK1AABL1BRAF | |
| SCHEMBL19670631 | 0.82 | FAAH (0.35) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |