Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 10/20 | 0.40 |
| ▸ | GSK3B | P49841 | 10/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670318 | 0.90 | MTOR (0.36) | WNT1GSK3BDYRK1AHDAC3HDAC4 | |
| SCHEMBL19670660 | 0.88 | HDAC3 (0.37) | WNT1GSK3BDYRK1AHDAC3HDAC4 | |
| SCHEMBL19670328 | 0.88 | DYRK1A (0.44) | WNT1GSK3BDYRK1AMTOR | |
| SCHEMBL16776409 | 0.88 | WNT1 (0.39) | WNT1GSK3BDYRK1AHDAC3HDAC4 | |
| SCHEMBL19865030 | 0.88 | DYRK1A (0.40) | WNT1GSK3BDYRK1ABRAF | |
| SCHEMBL17618856 | 0.86 | DYRK1A (0.39) | WNT1GSK3BDYRK1AHDAC3HDAC4 | |
| SCHEMBL19670492 | 0.84 | DYRK1A (0.42) | WNT1GSK3BDYRK1A | |
| SCHEMBL19670540 | 0.79 | DYRK1A (0.36) | WNT1GSK3BDYRK1ABRAFMTOR | |
| SCHEMBL19365415 | 0.78 | BRAF (0.41) | WNT1GSK3BDYRK1ABRAFCREBBP | |
| SCHEMBL19365492 | 0.78 | MTOR (0.36) | MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |