Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 9/20 | 0.39 |
| ▸ | FAAH | O00519 | 6/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670241 | 0.89 | GRM5 (0.38) | GRM5USP30 | |
| SCHEMBL19670263 | 0.89 | DHFR (0.37) | FAAH | |
| SCHEMBL19670385 | 0.87 | MPL (0.44) | MPLFAAHUSP30 | |
| SCHEMBL12654526 | 0.85 | MPL (0.42) | MPLGRM5FAAHCNR2AVPR1B | |
| SCHEMBL19670183 | 0.85 | GRM5 (0.36) | GRM5 | |
| SCHEMBL19670184 | 0.83 | MDM2 (0.39) | GRM5FAAHCNR2 | |
| SCHEMBL19865031 | 0.82 | CNR2 (0.46) | GRM5FAAHCNR2HSD11B1AVPR1B | |
| SCHEMBL17618739 | 0.82 | GRM5 (0.42) | MPLGRM5FAAHCNR2USP30 | |
| SCHEMBL19670122 | 0.81 | GRM5 (0.34) | GRM5HSD11B1 | |
| SCHEMBL17618517 | 0.81 | MPL (0.41) | MPLGRM5FAAHCNR2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |