Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYBB | P04839 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655361 | 0.85 | ROCK2 (0.36) | ROCK2TSHRGPBAR1 | |
| SCHEMBL19670357 | 0.85 | MPL (0.41) | GRM5 | |
| SCHEMBL17618360 | 0.81 | GRM5 (0.37) | GRM5HTTCYBB | |
| SCHEMBL17618645 | 0.80 | GRM5 (0.40) | GRM5HTT | |
| SCHEMBL19670155 | 0.79 | HDAC2 (0.36) | ROCK2MTORHTT | |
| SCHEMBL19670423 | 0.79 | TRPV3 (0.38) | ROCK2HTT | |
| SCHEMBL17655376 | 0.78 | HTR2A (0.37) | ROCK2TSHR | |
| SCHEMBL19670236 | 0.78 | DHODH (0.40) | ROCK2 | |
| SCHEMBL19670220 | 0.77 | ROCK2 (0.34) | ROCK2MTOR | |
| SCHEMBL19670179 | 0.77 | HTR2C (0.46) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |