Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 5/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670428 | 0.90 | ABL1 (0.40) | FAAHIRAK4PIM1GSK3BMAPK14 | |
| SCHEMBL19670257 | 0.89 | HPGDS (0.38) | IRAK4PIM1GSK3BMAPK14SLC5A1 | |
| SCHEMBL19670164 | 0.89 | GSK3B (0.40) | IRAK4PIM1GSK3BMAPK14SLC5A1 | |
| SCHEMBL19670357 | 0.87 | MPL (0.41) | MPLFAAHUSP30 | |
| SCHEMBL19670589 | 0.86 | HTR2C (0.42) | FAAHFYN | |
| SCHEMBL19670241 | 0.85 | GRM5 (0.38) | USP30 | |
| SCHEMBL19670263 | 0.85 | DHFR (0.37) | FAAHIRAK4 | |
| SCHEMBL19670590 | 0.83 | IRAK4 (0.41) | IRAK4PIM1FYNUSP30SLC5A1 | |
| SCHEMBL19670238 | 0.83 | TRPA1 (0.38) | IRAK4PIM1FYNUSP30TRPA1 | |
| SCHEMBL17618471 | 0.82 | MPL (0.45) | MPLFAAHIRAK4GSK3BMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |