Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365231 | 0.87 | GRM5 (0.37) | GRM5RAF1BRAFKMT2A | |
| SCHEMBL16238670 | 0.84 | GRM5 (0.34) | GRM5RAF1EGFRBTK | |
| SCHEMBL19670181 | 0.82 | RAF1 (0.35) | RAF1BRAFTRPV3TRPV1 | |
| SCHEMBL19365513 | 0.81 | PRMT5 (0.41) | — | |
| SCHEMBL19670357 | 0.81 | MPL (0.41) | GRM5HSD11B1 | |
| SCHEMBL19670575 | 0.81 | EGFR (0.32) | TRPV3EGFR | |
| SCHEMBL19865037 | 0.80 | GRM5 (0.36) | GRM5RAF1BRAFKMT2A | |
| SCHEMBL18415692 | 0.79 | GRM5 (0.36) | GRM5RAF1TRPV3KMT2A | |
| SCHEMBL19670392 | 0.79 | GRM5 (0.38) | GRM5BRAF | |
| SCHEMBL19670137 | 0.79 | ALDH1A1 (0.34) | RAF1TRPV3KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |