Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 11/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 4/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | DDT | P30046 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670572 | 0.88 | LMNA (0.35) | HDAC3HDAC1HDAC6HDAC2HDAC10 | |
| SCHEMBL19706003 | 0.83 | HDAC3 (0.40) | HDAC3HDAC1HDAC6HDAC2HDAC10 | |
| SCHEMBL16249981 | 0.82 | HDAC3 (0.40) | HDAC3HDAC1HDAC6HDAC2HDAC10 | |
| Hydrochloric Acid SCHEMBL16754672 | 0.82 | HDAC3 (0.40) | HDAC3HDAC1HDAC6HDAC2HDAC10 | |
| SCHEMBL19670249 | 0.77 | CA2 (0.42) | HDAC1 | |
| SCHEMBL19865051 | 0.77 | HDAC3 (0.37) | HDAC3HDAC1HDAC6HDAC2HDAC10 | |
| SCHEMBL19365749 | 0.76 | CA2 (0.42) | — | |
| SCHEMBL19865035 | 0.75 | CA2 (0.37) | — | |
| SCHEMBL17624670 | 0.75 | CA2 (0.39) | HDAC1 | |
| SCHEMBL16785533 | 0.74 | CA2 (0.37) | HDAC3HDAC1HDAC6HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |