Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.40 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670487 | 1.00 | KARS1 (0.40) | KARS1PRKD1DYRK1A | |
| SCHEMBL19670006 | 0.91 | KARS1 (0.40) | KARS1PRKD1DYRK1A | |
| SCHEMBL19669950 | 0.89 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19669954 | 0.89 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670507 | 0.87 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670514 | 0.87 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670631 | 0.86 | FAAH (0.35) | KARS1 | |
| SCHEMBL17618680 | 0.84 | KARS1 (0.42) | KARS1PRKD1 | |
| SCHEMBL17618657 | 0.84 | KARS1 (0.42) | KARS1PRKD1 | |
| SCHEMBL19365562 | 0.83 | MTOR (0.41) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |