Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669950 | 1.00 | KARS1 (0.34) | KARS1SCDHCRTR1FAAHWNT3A | |
| SCHEMBL19670006 | 0.90 | KARS1 (0.40) | KARS1FAAHDYRK1AITGB2ICAM1 | |
| SCHEMBL19670487 | 0.89 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19670396 | 0.89 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19670507 | 0.88 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670514 | 0.88 | KARS1 (0.34) | KARS1DYRK1A | |
| SCHEMBL19670631 | 0.85 | FAAH (0.35) | KARS1FAAHITGB2ICAM1ITGAL | |
| SCHEMBL17618688 | 0.85 | SCD (0.38) | KARS1SCDHCRTR1FAAHWNT3A | |
| SCHEMBL17618679 | 0.85 | SCD (0.38) | KARS1SCDHCRTR1FAAHWNT3A | |
| SCHEMBL19670490 | 0.84 | SLC34A1 (0.36) | KARS1SCDHCRTR1FAAHMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |