Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 4/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670431 | 0.90 | WNT1 (0.40) | MTORHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19670660 | 0.88 | HDAC3 (0.37) | MTORHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16776403 | 0.86 | MTOR (0.35) | MTORHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17618851 | 0.86 | KIF18A (0.36) | MTORHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19670434 | 0.85 | DYRK1A (0.34) | BRAFHTR1AWNT1GSK3BDYRK1A | |
| SCHEMBL19865030 | 0.78 | DYRK1A (0.40) | BRAFWNT1GSK3BDYRK1A | |
| SCHEMBL16776409 | 0.78 | WNT1 (0.39) | MTORHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19670328 | 0.77 | DYRK1A (0.44) | MTORWNT1GSK3BDYRK1A | |
| SCHEMBL19865057 | 0.76 | RHOA (0.41) | BRAFWNT1GSK3BDYRK1ACREBBP | |
| SCHEMBL19365415 | 0.76 | BRAF (0.41) | BRAFIMPDH2WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |