Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618789 | 0.87 | NAMPT (0.44) | MAPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19365629 | 0.85 | CHRM4 (0.41) | NAMPT | |
| SCHEMBL19365390 | 0.85 | DGAT2 (0.43) | CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL19361191 | 0.85 | NAMPT (0.42) | MAPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19670297 | 0.84 | ASAH1 (0.41) | NAMPT | |
| SCHEMBL19706062 | 0.83 | MAPK1 (0.43) | MAPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL19670650 | 0.83 | ASAH1 (0.44) | NAMPT | |
| SCHEMBL17618806 | 0.82 | NAMPT (0.39) | MAPK1NAMPT | |
| SCHEMBL19670440 | 0.82 | CA12 (0.42) | NAMPT | |
| SCHEMBL19670281 | 0.82 | LMNA (0.47) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |