Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670297 | 0.94 | ASAH1 (0.41) | CHRM4CTSKNAMPTCHRM2ASAH1 | |
| SCHEMBL19670650 | 0.91 | ASAH1 (0.44) | CHRM4NAMPTCHRM2ASAH1 | |
| SCHEMBL19670440 | 0.89 | CA12 (0.42) | CHRM4KMONAMPTCHRM2 | |
| SCHEMBL17618785 | 0.86 | CHRM4 (0.40) | CHRM4EPHB4ELANECTSKKMO | |
| SCHEMBL19670437 | 0.85 | MAPK1 (0.42) | NAMPT | |
| SCHEMBL19365390 | 0.83 | DGAT2 (0.43) | CHRM4KMOITGB3ITGA2BKCNH2 | |
| SCHEMBL19670281 | 0.82 | LMNA (0.47) | CTSKKCNH2 | |
| SCHEMBL17618790 | 0.81 | CHRM4 (0.41) | CHRM4EPHB4ELANEKMO | |
| SCHEMBL19670573 | 0.81 | MAPK10 (0.39) | — | |
| SCHEMBL19670497 | 0.80 | MAPT (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |