Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618794 | 0.86 | LMNA (0.43) | LMNACD274CNR2KCNH2CTSK | |
| SCHEMBL19670440 | 0.85 | CA12 (0.42) | CNR2TRPV4TSHR | |
| SCHEMBL19670537 | 0.84 | CNR2 (0.51) | LMNACNR2TRPV4 | |
| SCHEMBL19365834 | 0.84 | CNR2 (0.51) | LMNACNR2TRPV4 | |
| SCHEMBL19670297 | 0.83 | ASAH1 (0.41) | CTSKTRPV4DRD2EPHX2 | |
| SCHEMBL19670650 | 0.82 | ASAH1 (0.44) | CNR2TRPV4DRD2 | |
| SCHEMBL19365629 | 0.82 | CHRM4 (0.41) | KCNH2CTSK | |
| SCHEMBL17618787 | 0.82 | SMN1; SMN2 (0.45) | CNR2KCNH2CTSKTRPV4DRD2 | |
| SCHEMBL19670437 | 0.82 | MAPK1 (0.42) | LMNA | |
| SCHEMBL19670497 | 0.81 | MAPT (0.45) | LMNAEPHX2TSHRRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |