Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 0.51 |
| ▸ | HTR2A | P28223 | 12/20 | 0.51 |
| ▸ | HTR2B | P41595 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670564 | 0.86 | RHOA (0.46) | HTR2CHTR2AHTR2BMAPT | |
| SCHEMBL19365373 | 0.84 | KMO (0.39) | HTR2CHTR2ACYP1A2MAPT | |
| SCHEMBL16776360 | 0.83 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL19365254 | 0.82 | HTR2C (0.47) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL19365498 | 0.81 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL19706027 | 0.81 | RHOA (0.37) | KDR | |
| SCHEMBL19670427 | 0.81 | DYRK1A (0.39) | MAPK14 | |
| SCHEMBL12959003 | 0.80 | HTR2C (0.44) | HTR2CHTR2AHTR2BMAPTKIT | |
| SCHEMBL17618814 | 0.80 | HTR2C (0.46) | HTR2CHTR2AHTR2BCYP1A2MEN1 | |
| SCHEMBL12654500 | 0.79 | CA2 (0.44) | HTR2CHTR2AHTR2BCYP1A2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |