Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365498 | 0.95 | HTR2C (0.46) | HTR2CHTR2ACYP1A2HTR2BKIT | |
| SCHEMBL19365708 | 0.92 | MAPT (0.41) | HTR2CHTR2AKITTRPV1MAPT | |
| SCHEMBL19365904 | 0.91 | MAPT (0.43) | TRPV1MAPTMEN1KMT2AFAAH | |
| SCHEMBL19670179 | 0.90 | HTR2C (0.46) | HTR2CHTR2ACYP1A2HTR2BKIT | |
| SCHEMBL19365595 | 0.90 | MAPT (0.38) | HTR2CHTR2ACYP1A2HTR2BTRPV1 | |
| SCHEMBL19670146 | 0.88 | TSHR (0.45) | HTR2CHTR2ACYP1A2MAPTCYP3A4 | |
| SCHEMBL19365457 | 0.88 | MAPT (0.38) | HTR2CHTR2AKITTRPV1MAPT | |
| SCHEMBL19670144 | 0.87 | CHRM4 (0.37) | HTR2CHTR2AHTR2BTRPV1MAPT | |
| SCHEMBL19365744 | 0.86 | ABL1 (0.43) | HTR2CHTR2ACYP1A2HTR2BMAPT | |
| SCHEMBL19365568 | 0.85 | RHOA (0.50) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |