Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MARS1 | P56192 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964900 | 0.75 | HSP90B1 (0.46) | ADRA1DALDH1A1GRIN1GRIN2BPKM | |
| SCHEMBL1965863 | 0.74 | EGLN1 (0.45) | ALDH1A1PKMHIF1AKDM4ELMNA | |
| SCHEMBL1968380 | 0.71 | ALDH1A1 (0.42) | ADRA1DALDH1A1PKMCYP3A4KDM4E | |
| SCHEMBL1968383 | 0.71 | ALDH1A1 (0.42) | ADRA1DALDH1A1PKMCYP3A4KDM4E | |
| SCHEMBL8314773 | 0.62 | ALDH1A1 (0.72) | ALDH1A1AGTR1MEN1KMT2APKM | |
| SCHEMBL4375968 | 0.61 | NOX4 (0.46) | ALDH1A1AGTR1GRIN1GRIN2BMEN1 | |
| SCHEMBL30292038 | 0.61 | ADRA1D (0.46) | ADRA1DALDH1A1MEN1KMT2APKM | |
| SCHEMBL2970930 | 0.61 | ALDH1A1 (0.47) | ALDH1A1AGTR1MEN1KMT2APKM | |
| SCHEMBL1860321 | 0.61 | LMNA (0.53) | ALDH1A1GRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL15230184 | 0.60 | MAPT (0.46) | ADRA1DALDH1A1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |