Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618335 | 0.89 | TRPV1 (0.39) | FYNTRPV1CYP1A2HTR2AHTR2C | |
| SCHEMBL16237553 | 0.88 | FYN (0.37) | FYNTRPV1CYP1A2HTR2AHTR2C | |
| SCHEMBL19706043 | 0.87 | FYN (0.38) | FYNTRPV1CYP1A2HTR2AHTR2C | |
| SCHEMBL19670299 | 0.86 | FYN (0.43) | FYNTRPV1CYP1A2HTR2AHTR2C | |
| SCHEMBL19670497 | 0.86 | MAPT (0.45) | FYNTRPV1MAPTMEN1KMT2A | |
| SCHEMBL19365690 | 0.84 | FYN (0.38) | FYNTRPV1CA2CA9EPHB4 | |
| SCHEMBL20632114 | 0.83 | FYN (0.39) | FYNTRPV1CYP1A2HTR2AHTR2C | |
| SCHEMBL16237965 | 0.80 | KMT2A (0.37) | FYNTRPV1MAPTMEN1KMT2A | |
| SCHEMBL17618334 | 0.80 | TRPV1 (0.36) | FYNTRPV1CA2CA9EPHB4 | |
| SCHEMBL19365834 | 0.79 | CNR2 (0.51) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |