Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 2/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670299 | 0.93 | FYN (0.43) | MAPTMEN1KMT2AALDH1A1TRPV1 | |
| SCHEMBL19670466 | 0.88 | CA2 (0.41) | MAPTMEN1KMT2AALDH1A1TRPV1 | |
| SCHEMBL19365574 | 0.88 | CA2 (0.41) | MAPTMEN1KMT2AALDH1A1TRPV1 | |
| SCHEMBL19365834 | 0.88 | CNR2 (0.51) | LMNA | |
| SCHEMBL19670537 | 0.88 | CNR2 (0.51) | LMNA | |
| SCHEMBL19670552 | 0.86 | FYN (0.38) | MAPTMEN1KMT2AALDH1A1TRPV1 | |
| SCHEMBL17624594 | 0.84 | TRPV1 (0.39) | MAPTMEN1KMT2ATRPV1LMNA | |
| SCHEMBL19670476 | 0.84 | TRPV1 (0.46) | MAPTTRPV1KDR | |
| SCHEMBL19365413 | 0.84 | ADCY1 (0.50) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL19365865 | 0.84 | TSHR (0.36) | MAPTKMT2ATRPV1KDRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |