Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 5/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670537 | 1.00 | CNR2 (0.51) | CNR2THRBRHOAFAAHCNR1 | |
| SCHEMBL19670497 | 0.88 | MAPT (0.45) | LMNA | |
| SCHEMBL17618795 | 0.87 | CNR2 (0.49) | CNR2THRBRHOAFAAHCNR1 | |
| SCHEMBL19706080 | 0.84 | CNR2 (0.51) | CNR2THRBRHOAFAAHCNR1 | |
| SCHEMBL19670281 | 0.84 | LMNA (0.47) | CNR2LMNATRPV4 | |
| SCHEMBL19670299 | 0.83 | FYN (0.43) | LMNA | |
| SCHEMBL19365865 | 0.80 | TSHR (0.36) | FAAH | |
| SCHEMBL19670466 | 0.80 | CA2 (0.41) | THRBCNR1LMNA | |
| SCHEMBL19365574 | 0.80 | CA2 (0.41) | THRBCNR1LMNA | |
| SCHEMBL19865068 | 0.79 | CHRM3 (0.46) | CNR2FAAHCNR1UBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |