Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670497 | 0.93 | MAPT (0.45) | FYNTRPV1MAPTMEN1KMT2A | |
| SCHEMBL19670552 | 0.86 | FYN (0.38) | FYNTRPV1MAPTKDM1AMAOB | |
| SCHEMBL17618786 | 0.85 | FYN (0.42) | FYNTRPV1MAPTKDM1AMAOB | |
| SCHEMBL19365574 | 0.84 | CA2 (0.41) | TRPV1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19670466 | 0.84 | CA2 (0.41) | TRPV1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL19365834 | 0.83 | CNR2 (0.51) | LMNA | |
| SCHEMBL19670537 | 0.83 | CNR2 (0.51) | LMNA | |
| SCHEMBL19670476 | 0.83 | TRPV1 (0.46) | TRPV1MAPTMAPK1 | |
| SCHEMBL19365389 | 0.81 | FYN (0.44) | FYNTRPV1MAPTKDM1AMAOB | |
| SCHEMBL17624594 | 0.81 | TRPV1 (0.39) | FYNTRPV1MAPTKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |