Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | PNMT | P11086 | 6/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16648351 | 0.78 | DRD2 (0.37) | DRD2DRD3HTR6CA2 | |
| SCHEMBL27538780 | 0.77 | DRD2 (0.38) | DRD2DRD3CA2CA9CA1 | |
| Hydrochloric Acid SCHEMBL4715513 | 0.76 | DRD2 (0.36) | DRD2DRD3HTR6CA2 | |
| SCHEMBL20323430 | 0.76 | DAPK3 (0.42) | CA9 | |
| SCHEMBL29868930 | 0.74 | KMT2A (0.45) | DRD2DRD3HTR6PNMTHTR2A | |
| SCHEMBL4952656 | 0.74 | CA2 (0.58) | CA2CA9CA1 | |
| Hydrochloric Acid SCHEMBL29868424 | 0.74 | DRD2 (0.41) | DRD2DRD3HTR6PNMTHTR2A | |
| SCHEMBL20672086 | 0.73 | DRD2 (0.35) | DRD2DRD3HTR6MLNR | |
| SCHEMBL28277152 | 0.73 | DRD2 (0.35) | DRD2DRD3HTR6PNMT | |
| Hydrochloric Acid SCHEMBL4716276 | 0.73 | DRD2 (0.37) | DRD2DRD3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |