Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675647 | 0.77 | CA12 (0.46) | BRD4CREBBPGSK3B | |
| SCHEMBL19675765 | 0.73 | ALDH1A1 (0.38) | MEN1KMT2ACYP1A2PBRM1TNKS2 | |
| SCHEMBL14740800 | 0.72 | LMNA (0.34) | BRD4MEN1KMT2A | |
| SCHEMBL12140384 | 0.70 | BRD4 (0.40) | BRD4CREBBPMEN1KMT2AGSK3B | |
| SCHEMBL3407971 | 0.68 | CYP3A4 (0.40) | BRD4MEN1KMT2A | |
| SCHEMBL4631158 | 0.67 | MEN1 (0.42) | MEN1KMT2A | |
| SCHEMBL2529611 | 0.67 | MT-CO2 (0.42) | BRD4CREBBPGSK3B | |
| SCHEMBL19675235 | 0.67 | MEN1 (0.31) | MEN1KMT2AATM | |
| SCHEMBL17336857 | 0.67 | LMNA (0.36) | — | |
| SCHEMBL27827952 | 0.66 | MT-CO2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252049-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3252050-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-12-06 | — | — | EP | disclosed |