Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.38 |
| ▸ | KDM4A | O75164 | 4/20 | 0.38 |
| ▸ | KDM5C | P41229 | 4/20 | 0.38 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637624 | 0.86 | MCHR1 (0.46) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL16291545 | 0.78 | L3MBTL1 (0.54) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL15636850 | 0.73 | DRD4 (0.55) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL15636697 | 0.73 | KDM5C (0.48) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL15636721 | 0.71 | SIGMAR1 (0.52) | DRD2KDM5BKDM4AKDM5CKDM6B | |
| SCHEMBL15636644 | 0.71 | KDM5B (0.51) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL20779104 | 0.70 | SIGMAR1 (0.43) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL19574680 | 0.69 | TSHR (0.43) | KDM5BKDM4AKDM5CKDM5AKDM6B | |
| SCHEMBL15635975 | 0.68 | SIGMAR1 (0.58) | KMT2AALDH1A1POLBHTTMEN1 | |
| SCHEMBL17710855 | 0.65 | CXCR4 (0.60) | DRD2HTR2ADRD3KDM5BKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |