Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | KDM4A | O75164 | 2/20 | 0.57 |
| ▸ | KDM4B | O94953 | 2/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845355 | 0.90 | NPC1 (0.52) | NPC1RAB9AKDM4AKDM4BKDM5B | |
| SCHEMBL77592 | 0.85 | SMN1; SMN2 (0.77) | NPC1RAB9AKDM4AKDM4BKDM5B | |
| SCHEMBL8890163 | 0.85 | GRM5 (0.58) | NPC1RAB9ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL741587 | 0.82 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL3610148 | 0.81 | FFAR2 (0.51) | NPC1RAB9ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL13055749 | 0.80 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2ADORA3TAS1R3 | |
| SCHEMBL3791723 | 0.80 | KMT2A (0.53) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL16318533 | 0.80 | GCK (0.52) | NPC1RAB9ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL16321719 | 0.78 | ALOX15 (0.49) | NPC1RAB9ASMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL13055750 | 0.78 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |