Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968290 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL14306296 | 0.81 | KCNN4 (0.43) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL4450821 | 0.81 | KCNN4 (0.43) | ALDH1A1LMNAMAPTMEN1KMT2A | |
| SCHEMBL17472948 | 0.80 | MEN1 (0.37) | MEN1KMT2A | |
| SCHEMBL29226417 | 0.75 | ALDH1A1 (0.46) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL29226421 | 0.75 | ALDH1A1 (0.46) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL1968660 | 0.75 | MAPT (0.51) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL11117316 | 0.75 | ALDH1A1 (0.50) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL1968816 | 0.75 | MAPT (0.51) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL1970323 | 0.73 | MEN1 (0.65) | ALDH1A1LMNAALOX15APEX1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168667-B2 | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such | GALAPAGOS NV (BE) | 2012-05-01 | — | — | US | disclosed |
| EP-2026799-B1 | IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH | GALAPAGOS SAS (FR) | 2011-06-22 | — | — | EP | disclosed |