Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 3/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | GPR39 | O43194 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686669 | 0.80 | IL1B (0.38) | IDH1NUDT1IDH2HRH4 | |
| SCHEMBL21144067 | 0.79 | KCNN2 (0.52) | IDH1MKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL19687218 | 0.78 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19686523 | 0.75 | IDH1 (0.44) | IDH1IDH2 | |
| SCHEMBL19687150 | 0.72 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19687174 | 0.72 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19687151 | 0.70 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19687152 | 0.70 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19687411 | 0.69 | IDH1 (0.39) | IDH1IDH2ADORA2AADORA1 | |
| SCHEMBL19687470 | 0.69 | IDH1 (0.39) | IDH1IDH2GPR39 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |