Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSH | P09668 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19972765 | 0.85 | CTSK (0.56) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL19972768 | 0.85 | CTSK (0.56) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL23023464 | 0.84 | CTSK (0.55) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL17646358 | 0.83 | CTSK (0.55) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL17665993 | 0.83 | CTSK (0.55) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL17661708 | 0.80 | CTSK (0.49) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL17661705 | 0.80 | CTSK (0.49) | CTSKCTSHCTSBCTSLCTSS | |
| SCHEMBL19983106 | 0.79 | CTSK (0.48) | CTSKCTSHCTSB | |
| SCHEMBL25658991 | 0.78 | CTSK (0.46) | CTSKCTSHCTSL | |
| SCHEMBL19972757 | 0.74 | CTSK (0.40) | CTSKCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349537-A1 | INHIBITORS OF LYSINE GINGIPAIN | ENPEP, PHYKPL, PREP | CTSK 631/4885CTSH 1501/4885CTSB 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.